At 24 h post-treatment, there was a noticeable decline in embryo hatching rates, with a 40% decrease in the case of CML co-injected with rHDL-2 and a 60% decrease with rHDL-3, when compared to CML co-injected with rHDL-1. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.