However, polymorphisms in perilipin 4 (PLIN4; −11482G > A), FM and obesity-associated (FTO; rs9939609 (A/T)), and β-adrenergic receptor 3 (ADRB3; Trp64Arg) attenuated its lipolysis effect. The gene discussed is PLIN4; the disease is obesity due to melanocortin 4 receptor deficiency.