Dihydrosanguinarine (52) inhibits pancreatic cancer cells by downregulating mut-p53 or wt-p53 protein expression and regulating the RAS/Raf/MEK/ERK pathway, and the mechanism may be correlated with inducing apoptosis in PANC-1 and SW1990 cells and triggering cell cycle arrest in PANC-1 cells [75]. Here, TP53 is linked to familial pancreatic carcinoma.