NFKB1 and tongue squamous cell carcinoma: To be specific, the mechanism of action against human tongue squamous cell carcinoma may be inhibiting NF-κB activation, downregulating BcI-2 protein expression on mRNA, and reducing telomerase activity; inhibiting non-small cell lung cancer A549 cell proliferation, migration, and inducing apoptosis; inhibiting proliferation and migration and upregulating the intracellular NF-κB p65 expression of the subunit [51].