XIAP and melanoma: As a result, sanguinarine caused a decrease in the mitochondrial membrane potential and levels of antiapoptotic proteins of the bcl-2 protein family, BCL XL, and myeloid cell leukemia protein 1 (Mcl-1), as well as downregulated levels of the X-linked inhibitor of apoptosis protein (XIAP) to facilitate melanoma cell apoptosis.