Chelerythrine (2) can act on tgfb1-erk1/2/Smad2/3-snail/ZEB1 signaling to inhibit the progression of cell lines U251 and T98G of glioblastoma (GBM) (e.g., proliferation, migration, stemness, and invasion [33]). The gene discussed is ZEB1; the disease is glioblastoma.