HMGB1 and Sepsis: Given these research-based findings for S. baicalensis and A. catechu, in the present study, we evaluated the effect of an antioxidant botanical composition (UP446) on the level of HMGB1 release from hyperoxia-stressed macrophages in vitro and assessed its impact on survival in a lipopolysaccharide (LPS)-induced sepsis and acute inflammatory lung injury model.