NFKB1 and neoplasm: As the NF-κB pathway activates the expression of genes implicated in inflammation that can lead to chronic inflammation, tumor development, or proliferation, the Nrf2 pathway displays important antioxidant roles, such as mediating the release of ROS (reactive oxygen species) induced by NF-κB or suppressing the transcription of NF-κB-dependent pro-inflammatory genes [14].