Baicalin treatment (20 and 40 mg/kg bodyweight) modulated Sirt1 and downregulated the level of Rela acetylation in the hippocampus and hypothalamus and the levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in mice with depression, suggesting that administration of baicalin may alleviate depression by modulating the Sirt1-NF-κB pathway [38]. Here, TNF is linked to major depressive disorder.