Lin et al. reported that 8 weeks of treatment with baicalin (400 mg/kg bodyweight) alleviated liver fat accumulation, dysregulated blood lipids, weight loss, and insulin sensitivity in the HFD-induced metabolic syndrome (MetS) mouse model through the regulation of citric acid cycle (tricarboxylic acid (TCA) cycle), alanine, aspartic acid, and glutamic acid metabolism, and glycerol phospholipid metabolism. Here, INS is linked to metabolic syndrome.