In the second phase of the study, it was observed that higher expression of AC000120.7 (median: 0.02860, 95% CI: 0.01911 to 0.03533 vs. 0.01097, 95% CI: 0.003105 to 0.02078, effect size: 1.6139, actual power: 0.9636142, p = 0.0280) and SENP3-EIF4A1 (median: 0.01065, 95% CI: 0.006911 to 0.01781 vs. 0.003380, 95% CI: −0.001671 to 0.01220, effect size: 1.062352, actual power: 0.9506665, p = 0.0400) remained in patients diagnosed with ARDS-CoV-2 compared to patients with ARDS (Figure 2a,b). This evidence concerns the gene SENP3 and acute respiratory distress syndrome.