Finally, the impact of SENP3-EIF4A1 in inhibiting miR-195-5p, along with its subsequent effects on the inhibition of inflammatory factors such as VEGFA, the modulation of the TLR2 inflammatory pathway, and the potential attenuation of pro-inflammatory cytokine production in COVID-19, remain areas that require further investigation. This evidence concerns the gene SENP3 and COVID-19.