MUC5AC and Alzheimer disease: Based on the existing studies, we suggest that DH may promote the differentiation of IEC by increasing the abundance of Akkermansia in the intestine of AD mice, which promotes the synthesis and secretion of mucin, increases the thickness of the intestinal mucosa, restores the integrity of the intestinal barrier, alleviates the pathological changes in the colon, and reduces the deposition of Aβ.