Dapsone (DDS) alone or in combination with other antibiotics (doxycycline) has been proposed as a potential treatment for those with COVID-19 due to the drug’s combined effects in blocking inflammatory storms and suppressing the production of cytokine signatures including IL1α, IL8, IL1β, IL6, and IL8 and tumor necrosis factor-α [197,198]. The gene discussed is IL1B; the disease is COVID-19.