In a meta-analysis of five RCTs that included women with gestational diabetes, probiotic supplementation led to a significant reduction in CRP (p < 0.0001), IL-6 (p = 0.0005), and malondialdehyde (MDA) (p < 0.00001), and an increase in NO (p = 0.003) and total antioxidant capacity (TAC) (p = 0.01) [65]. The gene discussed is IL6; the disease is gestational diabetes.