From these results, serum resistin levels (OR: 1.090, 95% CI: 1.032–1.152, p = 0.002), DM (OR: 2.373, 95% CI: 1.161–4.852, p = 0.018), age (OR: 1.063, 95% CI: 1.031–1.095, p < 0.001), and body weight (OR: 1.057, 95% CI: 1.009–1.007, p = 0.019) surfaced as independent predictors of aortic stiffness in non-dialysis-dependent CKD patients, revealing the intricacies of the aortic stiffness-related factors as per our multivariable logistic regression analysis (Table 2). The gene discussed is RETN; the disease is diabetes mellitus.