Adipose tissue contributes to the appearance and development of colorectal cancer by increasing the secretion of adipokines, proinflammatory cytokines (interleukin-6, tumor necrosis factor alpha, plasminogen activator inhibitor 1—PAI-, etc.), insulin or insulin-like growth factor (IGF), respectively, the decrease in adiponectin secretion [51,52,54]. Here, SERPINE1 is linked to colorectal cancer.