The expression of cytokines such as IL-1A, IL-1B, IL-6, INF-γ, and TGF-β is higher in penile cancer, but it is not associated with penile cancer progression or patients survival, while a positive correlation between INF-γ levels in cancer samples and clinical advancement may be associated with the immunosuppressive role of the tumor environment. This evidence concerns the gene IL1A and penile cancer.