Additionally, five lncRNAs associated with prognosis, including lncRNA-ATB [48], lncRNA CTD-2116N20.1 [49], lncRNA RP11538D16.2 [49], lncRNA CRNDE [50], and lncRNA ASMTL-AS1 [51], were found to be significantly upregulated in the serum EVs of HCC patients and associated with prognosis. This evidence concerns the gene ASMTL and hepatocellular carcinoma.