AFP and hepatocellular carcinoma: Notably, the EVs-miR-HCC Score system, which includes serum AFP, plasma EV miR-21-5p, and EV miR-92a-3p, has been shown to outperform AFP alone, with an area under the curve (AUC) of 0.85 compared to 0.72 for AFP-based HCC diagnosis, according to Sorop et al. [29].