TTN and familial dilated cardiomyopathy: Tayal et al. [5] proposed the concept of a ‘core disease set’, which accounts for some key mutations in DCM, including the sarcomere genes MYH7 (encoding beta-myosin heavy chains), TNNT2 (encoding troponin T2), TTN (encoding titin), and the LMNA gene, which encodes a nuclear membrane protein.