TNF and Hypertension: A meta-analysis by Zhao et al., which included 6321 patients with RA from 11 randomized clinical trials, reported strong evidence of an increased incidence of hypertension associated with some anti-TNF therapies (OR = 1.8896, 95% CI: 1.35–2.65) as well as an increasing incidence of hypertension with longer therapy duration, especially for certolizumab but not for etanercept, tofacitinib, infliximab, and golimumab [126].