PTGS2 and Stroke: Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors (COX2 inhibitors) have good anti-inflammatory and analgesic effects, but they increase the risk of acute CV diseases, particularly stroke and myocardial infarction; this occurs particularly with diclofenac and rofecoxib [32,86,87,88,89,90,91,92].