TNF and infection: A large meta-analysis, which included 43 biological registers and 27 publications, addressed the issue of biologics safety and effect on mortality, and it reported that overall mortality and CV events were significantly reduced in patients treated with anti-TNFs: RR = 0.60 [95% CI 0.38–0.94] and RR = 0.62 [95% CI 0.44–0.88], respectively, with no effect on neoplasm risk; however, serious infections significantly increased during anti-TNF treatment (RR = 1.48 [1.18–1.85]) compared to classical DMARD treatment [123].