Endothelial dysfunction in RA can be assessed measuring circulating soluble adhesive molecules, such as E-selectin, P-selectin, intracellular adhesion molecule-1 (ICAM-1), vascular cell type 1 adhesion molecule (VCAM-1), and flow-mediated arterial dilatation, all of which are suggested for use in CV risk assessment; these methodologies are supported by a meta-analysis involving 20 studies including 852 patients with RA [83]. This evidence concerns the gene VCAM1 and endothelial dysfunction.