NKRF and cancer: Flavonoids’ ability to inhibit the growth and proliferation of several cancer cell types has been linked to a number of different mechanisms of action, including the expression of tumor suppressor genes and oncogene control; the induction of cell cycle arrest and apoptosis involving the p53, Bcl-2 and families of caspase activation; and the inhibition of signal transduction pathways such as Nrf, NF-κB, AP-1, Wnt/β-catenin, MAPK and growth factors [44].