In the inflammatory tumor microenvironment (TME), there is an increase in DNA and protein damage, activation of oncogenes, and release of ROS which ultimately affect multiple signaling pathways such as nuclear factor-kB (NF-kB), Kirsten rat sarcoma virus (K-RAS), Janus kinase/signal transducer, and activator of transcription 3 (JAK/STAT3). This evidence concerns the gene STAT3 and neoplasm.