Based on this theoretical framework, it is postulated that a patient diagnosed with chronic rhinosinusitis with nasal polyps (CRSwNP) who exhibits a preoperative eosinophil cationic protein (ECP) level below a specified threshold of 21.8 U/mL is highly likely, with a 95% probability, to achieve a satisfactory surgical outcome, provided that there is no occurrence of early polyp recurrence [16]. This evidence concerns the gene RNASE3 and chronic rhinosinusitis.