Inflammation could be possibly activated by a biochemical, metabolic, or hemodynamic process present in DN [48], with the IL-18, IL-6, TNF-alfa, and TNF-beta1 being at high levels in the circulating blood supply [30]; their role in DN’s evolution has already been proved, with other studies reporting that their levels rise with the aggravation of the disease [49]. The gene discussed is IL6; the disease is liver dysplastic nodule.