INS and diabetes mellitus: A constant level of elevated blood glucose and insulin resistance can cause significant vascular deterioration, resulting in neuropathy, nephropathy, retinopathy, and cardiovascular diseases, including a course of peripheral arterial disease; they all contribute to both the mortality and morbidity of diabetes mellitus type 1 and 2, [12], a diabetic patient having a risk up to three times higher of premature death with their life expectancy being shorter by 8 years [13].