In all patients, but especially in men with testosterone levels in the “gray zone” and sexual symptoms of MH, calculated free testosterone (cFT) determination, obtained by dosing testosterone, albumin and SHBG levels, allows a more accurate diagnosis of hypogonadism, since total testosterone determination alone misdiagnoses hypogonadism in about 8% of men with sexual symptoms [8]. This evidence concerns the gene ALB and hypogonadism.