CT, fMRI, PET, EEG, polysomnography scan 6-sulphatoxymelatonin (aMT6) collected every 2 to 8 h. over 24 to 48 h period, melatonin, Timeless, period 1–3, growth hormone (SOCS) [133] Actiwatch (sleep quality, duration), Urine: 6-sulphatoxymelatonin (good biomarker); Melatonin in blood and saliva (not accurate), core body temperature (susceptible to masking), GI microbiome, genotype changes—per3 polymorphisms (human), Dqb10602 gene (narcolepsy), Immune markers—IL6; behavioral tests; NIRS/fNIRS. Here, CISH is linked to narcolepsy.