Long-term chronic stress featured with high levels of cortisol and IL-1β can cause disorders of intestinal flora composition, one recent study showed that the depression mice model established by Chronic Unpredictable Mild Stress (CUMS) had obvious intestinal flora disorder and Cinnamon Oil Solid Self-Microemulsifying Drug Delivery System (CO-S-SME) changed the intestinal flora composition by decreasing the ratio of Firmicutes to Bacteroidetes, reducing relative abundances of Lactobacillus, modulating Alpha diversity and Beta diversity [45]. Here, IL1B is linked to major depressive disorder.