[68Ga]Ga-FAPI-04 PET/CT showed a higher sensitivity than [18F]FDG PET/CT in detecting intrahepatic HCC lesions (85.7% vs. 57.1%, particularly in patients with cirrhosis, low alpha-fetoprotein, multiple HCCs, and non-serious microvascular invasion), small (≤2 cm in diameter; 68.8% vs. 18.8%) and well- or moderately-differentiated HCCs (83.3% vs. 33.3%). This evidence concerns the gene AFP and Cirrhosis.