Another limiting factor is the fact that most patients with hypertension received medications prescribed for HF [e.g., angiotensin receptor blockers (67% of patients), beta blockers (39%), mineralocorticoid receptor antagonists (6%), and thiazide diuretics (33%)]; the use of these medications may have led to a reduction in their NP levels and misclassification of subjects. The gene discussed is NR3C2; the disease is hydrops fetalis.