Serum NT-proBNP levels were higher in CHF compared to both obese and hypertensive patients [1232 pg/mL (566, 3509) vs. 64 pg/mL (<60, 93) vs. 106 pg/mL (63, 120), respectively (p < 0.05)] but there was no significant difference in saliva NT-proBNP levels among the three groups of patients [8.6 pg/mL (7.1, 35.2) vs. 8.8 pg/mL (6.3, 22.7) vs. 11.1 pg/mL (6.0, 17.6), respectively (p = 0.969)]. This evidence concerns the gene NPPB and congestive heart failure.