In their initial study including 17,182 patients, Jaiswal et al. found that the presence of somatic mutations of genes associated with hematological malignancies in peripheral blood cells was associated with an increased risk of overall mortality (HR 1.4; 95% CI 1, 1–1.8), ischemic heart disease (HR 2.0; 95% CI 1.2–3.4), and ischemic stroke (HR 2.6; 95% CI 1.4–4.8), subsequently corroborating this relationship between CHIP and greater atherogenesis in animal models [9,25]. This evidence concerns the gene STUB1 and ischemic stroke.