For example, a decrease in methylation due to a mutation of DNMT3a in a specific gene was associated with an increase in the expression of NEAT1, which is related to inflammation and atherosclerosis, while the increase in methylation associated with mutations in TET2 was associated with a decrease in the expression of STAT6, which is associated with greater instability of the atherosclerotic plaque [33]. The gene discussed is STAT6; the disease is atherosclerosis.