In the patients analyzed in our study, the severity of the disease is evidenced by the high value of the nasal polyp score at time T0, the clinical history usually associated to comorbidities such as bronchial asthma, the recurrence of the disease after endoscopic nasal surgery, and again by the high value of total blood IgE and the basic blood eosinophilia level. The gene discussed is IGHE; the disease is nasal cavity polyp.