This tumor suppressor gene located on chromosome 16q22.1, which encodes the E-cadherin glycoprotein, is associated with cell adhesion for the formation of complex tissues associated with other proteins, in which mutations in the CDH1 gene with loss of function of its protein can lead to cell–cell adhesion instability and important signaling failure in the pathways in which they act [11]. The gene discussed is CDH1; the disease is neoplasm.