Cardiac biomarkers, such as cardiac troponins and N-terminal pro-B-type natriuretic peptide (NT-proBNP), were shown to predict the risk of all-cause mortality in patients with cardiovascular disease, such as AMI, acute and chronic heart failure (HF) and ventricular tachyarrhythmias, as well as in patients with non-cardiac diseases such as in patients with stroke or sepsis [14,18,19,20,21]. The gene discussed is NPPB; the disease is Sepsis.