The prognostic impact of NT-proBNP was confirmed by Sharma et al. in 42 patients with STEMI-related CS, suggesting reliable prediction of in-hospital mortality (AUC = 0.748) [26], which may be attributed to more advanced stages of left ventricular dysfunction but may be aggravated by prevalent acute kidney injury or concomitant sepsis. This evidence concerns the gene NPPB and acute kidney injury.