The authors reported the treatment for the three major BS phenotypes: patients with the “mucocutaneous and articular” phenotype should be treated with colchicine, alone or in combination with corticosteroids; AZA can be used in case of resistance or intolerance to colchicine; and anti-TNFα or IFNα should be considered for refractory or severe forms. The gene discussed is TNF; the disease is Bloom syndrome.