However, the Glycemic Effects in Diabetes Mellitus Carvedilol—Metoprolol Comparison in Hypertensive study (GEMINI) demonstrated that b-blockers a-adrenergic effects, such as carvedilol, improve insulin sensitivity, slower progression of microalbuminuria in diabetes and have a safer metabolic profile than cardioselective b-blockers, such as metoprolol [100,101,102]. The gene discussed is INS; the disease is diabetes mellitus.