Another concern arising from the study of leptin and adiponectin in overweight/obesity in children/adolescents regards the different expression of these adipokines according to sex and age; in fact, hormonal differences between boys and girls and between prepubertal and postpubertal individuals of both sexes are major determinants of the levels of plasma adipokines [58]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.