Similarly to us, Sanchez-Hidalgo et al. observed that an MLT (2 mM) treatment in Burkitt- and DLBCL-derived cell lines contributed to the activation of caspase-8 and, simultaneously, to caspase-3 and -9 activation, as well as a reduction in the ΔΨ. Here, CASP8 is linked to diffuse large B-cell lymphoma.