Only NLRP3 had a significant contribution to the likelihood of depression analyzed with age, body mass index, diabetes comorbidity, use of additional medication, Gensini score, duration between myocardial infarction, and blood collection as covariates (p = 0.015, OR = 1.72, and CI = 1.11-2.66). The gene discussed is NLRP3; the disease is myocardial infarction.