Analyzing gene expressions in conjunction with the serum levels of the inflammatory parameters, while also assessing the other components of the pathway and inflammasome complexes, such as toll-like receptors, ASC, pro-caspase-1, caspase-1, pro-IL-1β, and pro-IL-18, would have provided a better understanding of the pathway and its role in depression–myocardial infarction comorbidity. This evidence concerns the gene IL1B and major depressive disorder.