Tissue factor pathway inhibitor is found to be one of the major determinants to prolong lag time and reduce ETP in the presence of APC and ETP ratios with/without APC lowering the APC resistance in TG [31], and it is known to be elevated in presence of co-morbidities such as obesity and diabetes mellitus [75], which may lead to a higher mortality rate. This evidence concerns the gene F3 and diabetes mellitus.