Regarding the etiological assessment and management, each of the patients had a thrombophilia assessment during the diagnosis of adrenal necrosis with search for an antiphospholipid syndrome (lupus circulating anticoagulant = antiprothrombinase antibody, anticardiolipin antibody, antibodies toβ2Gp1), constitutional thrombophilia (assay of protein S, protein C, antithrombin and search for factor II and factor V mutations), myeloproliferative syndrome (JAK2 mutation) and paroxysmal nocturnal hemoglobinuria (PNH clone). The gene discussed is PROS1; the disease is thrombophilia.