PAPPA and diabetes mellitus: In these softwares, physicians can type in the data of the mothers (e.g., age, height, weight, race, family history, smoking, preliminary type I or II diabetes, preexisting chronic hypertension, SLE, and APS) and also the biophysical measurements of the fetus (e.g., mean arterial pressure and mean uterine artery PI); some softwares even count with the above-mentioned preeclampsia biomarkers, such as serum PlGF and serum PAPP-A (pregnancy-associated plasma protein A).