ALB and Hypoalbuminemia: In particular, Chahrour MA et al. (2021) retrospectively explored data from 35,383 patients undergoing lower limb amputation to investigate the relationship between preoperative hypoalbuminemia and postoperative mortality; the authors concluded that the mortality rate was higher in patients with very low serum albumin concentration (<2.5 g/dL) compared to low (2.5–3.39 g/dL) and normal levels (≥3.4 g/dL) (11%, 6.8%, and 3.9%, respectively), even after adjusting for confounding variables [46].