ARCI is caused by mutations in more than a dozen different genes, including TGM1 (Transglutaminase-1), ABCA12 (ATP-binding cassette sub-family A member 12), CYP4F22 (Cytochrome P450 4F22), ALOXE3/ALOX12B (epidermal lipoxygenase-3/12R-lipoxygenase), NIPAL4 (magnesium transporter NIPA4), CERS3 (ceramide synthase-3), SDR9C7 (short-chain dehydrogenase/reductase family 9C member 7), PNPLA1 (patatin-like phospholipase domain-containing protein 1), SLC27A4 (long-chain fatty acid transport protein 4), and LIPN (epidermal lipase N) [4]. Here, PNPLA1 is linked to autosomal recessive congenital ichthyosis.