Mean scores of our AS population are approximately 2 points below the mean scores of PWS, Bardet Biedl Syndrome, and Alström Syndrome, and they are 6–7 points below the mean of children with defects in the leptin–melanocortin pathway, regulating hunger and satiety (Table A3 in the Appendix A). The gene discussed is LEP; the disease is Alstrom syndrome.