In a cohort of 137 iTTP survivors followed for a median observation period of 3.08 years, the risk of stroke during clinical remission was increased nearly five-fold (13.1% vs. 2.6%) compared with an age- and sex-matched control population, and this risk was strongly associated with suboptimal ADAMTS13 recovery during clinical remission [15]. The gene discussed is ADAMTS13; the disease is stroke disorder.