SERPINA1 and chronic obstructive pulmonary disease: Patients with COPD and alpha-1 antitrypsin deficiency (AATD), a disease that causes the development of COPD in young populations due to a deficiency in alpha-1 antitrypsin, had a higher prevalence of periodontitis (COPD 95%, AATD 88%) than the prevalence reported by unselected community residents (data were taken from NHANES and the UK Adult Dental Health Survey in 2009), even after accounting for risk factors.