ALB and Sepsis: In addition, in the ‘Volume Replacement With Albumin in Severe Sepsis’ (ALBIOS) study, which compared the administration of 20% HA, dosed by albumin serum levels, in sepsis patients with 0.9% NaCl, it was confirmed that during the first seven days, patients in the HA group, as compared with those in the crystalloid group, had a higher MAP and lower net fluid balance [36].