The role of NT-pro BNP is also influenced by the management carried out; in the study of Safi et al. (2017), a significant decrease in NT-pro BNP was found after the percutaneous mitral commissurotomy intervention in RHD mitral stenosis patients, and the decrease in value correlated with a decrease in the mean pressure gradient (MPG) [53]. The gene discussed is NPPB; the disease is mitral valve stenosis.