NFKB1 and aneurysm: A number of intracellular and extracellular signaling pathways have been found to be associated with aneurysm development in the aorta; one is the MAPK/ERK pathway, which, through sequential kinase activation, triggers NF-Kβ expression [39], although impairment of the AKT2 pathway may also contribute to aneurysm formation [40,41].