Sjögren’s syndrome (SS) is a rheumatic disease characterized by sicca symptoms due to lymphocytic infiltration of the exocrine glands and the emergence of autoantibodies such as anti-Ro/SS-A and La/SS-B antibodies.Anti-Ro/SS-A and La/SS-B antibodies are crucial items for the diagnosis of SS adopted in the 2002 American-European Consensus Group SS classification criteria [1] as well as pathogenic in neonatal lupus [2]. The gene discussed is CALR; the disease is rheumatic disorder.