In this regard, our group [166] studied in the SysPharm PediA cohort a group of European children from four different countries diagnosed with moderate and severe asthma, observing that CpG cg12835256 (PLA2G12A gene) was significantly associated with FeNO, and three CpGs were associated with BDT, highlighting CpG cg26203256 (ADD3-AS1 gene). Here, ADD3 is linked to asthma.