In patients with APS, there is an association between the risk of developing NBTE, the presence of lupus anticoagulant (LAC), anti-cardiolipin, and anti-beta-2-glycoprotein I antibodies of the IgG isotype, as well as the presence of two or more antiphospholipid antibodies [8]. This evidence concerns the gene APOH and autoimmune polyendocrinopathy.