Some of the abbreviations used throughout this paper include: (CLS)—crown-like structures, (MCP-1)—monocyte chemoattractant protein-1, (TNF-α)—tumor necrosis factor Î±, (FFA)—free fatty acids, (JNK)—c-Jun N-terminal kinase, (IL-6)—interleukin 6, (SOCS-3)—suppressor of cytokine signaling protein 3, (IRS-1)—insulin receptor substrate 1, (IR)—insulin resistance, (DMt2)—diabetes mellitus type 2. The gene discussed is IRS1; the disease is Insulin resistance.