ACE2 and obesity due to melanocortin 4 receptor deficiency: In pregestational diabetes, due to the expression of ACE2 increased in tissues of the lung, inflammation, insulin resistance, and altered immune modulation by an increase in pro-inflammatory cytokines, and in the case of obesity also due to ACE2 overexpression in adipocytes, a pro-inflammatory state, and a reduced lung capacity, may contribute to this increased risk...